Macroporous ceramics of carbonated hydroxyapatite for bone grafting applications
Résumé
Calcium phosphate based materials, specifically hydroxyapatite (HA) and tricalcium phosphate (TCP), have been extensively used as bone graft substitutes for various applications (e.g. bone augmentation procedure). They temporarily substitute for bone while simultaneously supporting its regeneration. However, they present inappropriate resorption rate. Indeed, ideally a bone substitute should degrade only after the regenerated tissue has been remodelled at least once in the natural remodelling cycle [1]. Thus, the solubility of HA is too slow and that of TCP too fast to foster successful bone re-growth. To further improve the properties of calcium phosphate ceramics, ionic substitutions could be used. One way to modulate their resorption rate would be to substitute carbonate ions (CO3 2-) for phosphate ones (PO43-) into the HA structure [2]. Thus, the aim of the present work was to elaborate interconnected macroporous scaffold of pure carbonated hydroxyapatite (CHA). REFERENCES: 1 M. K. Heljak et al. (2012) Int. J. Numer. Meth. Biomed. Engng. 28:789-800. 2 Y. Doi et al. (1998) J. Biomed. Mater. Res. 39:603-610.
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