The paper applies an Efficient Global Optimization method (EGO) to improve the efficiency, in flux weakening region, of a given 5-phase Permanent Magnet (PM) machine. An optimal control for the four independent currents is thus defined. Moreover, a modification proposal of the machine geometry is added to the optimization process of the global drive. The effectiveness of the method allows solving the challenge which consists in taking into account inside the control strategy the eddy-current losses in magnets and iron. In fact, magnet losses are a critical point to protect the machine from demagnetization in flux-weakening region. But these losses, which highly depend on magnetic state of the machine, must be calculated by Finite Element Method (FEM) to be accurate. The FEM has the drawback to be time consuming. It is why a direct optimization using FEM is critical. EGO method, using sparingly FEM, allows to find a feasible solution to this hard optimization problem of control and design of multi-phase drive.