Irganox 1010 stabilized PE was monitored by carbonyl build-up and DSC under oxygen. A scheme for PE stabilization by phenols was implemented and its kinetic parameters were calculated from experimental results. This model was validated from its ability to simulate kinetics curves for carbonyl build up, induction period changes with stabilizer concentration, and stabilizer depletion curve in thermal ageing. The use of OIT measurement for quantifying stabilizer is also discussed. Kinetic analysis showed that OIT is actually proportional to stabilizer concentration in virgin samples but this is not true for aged samples because of negative influence of oxidation unstable by-products. The model was also employed for discussing some scenarii proposed as explanation of heterogeneity observed during thermal oxidation of stabilized polyolefins.