Copper-catalyzed oxidative diamination of terminal alkynes by amidines: synthesis of 1,2,4-trisubstituted imidazoles. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Organic Letters Année : 2013

Copper-catalyzed oxidative diamination of terminal alkynes by amidines: synthesis of 1,2,4-trisubstituted imidazoles.

Résumé

An efficient copper-catalyzed synthesis of 1,2,4-trisubstituted imidazoles using amidines and terminal alkynes has been developed. Overall, the oxidative process, which involves Na2CO3, pyridine, a catalytic amount of CuCl2*2H2O, and oxygen (1 atm), consisted of a regioselective diamination of alkynes allowing the synthesis of diverse imidazoles in modest to good yields.

Domaines

Chimie organique
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Dates et versions

hal-00853255 , version 1 (22-08-2013)

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Citer

Jihui Li, Luc Neuville. Copper-catalyzed oxidative diamination of terminal alkynes by amidines: synthesis of 1,2,4-trisubstituted imidazoles.. Organic Letters, 2013, 15 (7), pp.1752-5. ⟨10.1021/ol400560m⟩. ⟨hal-00853255⟩
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