Gastrointestinal manifestations in mastocytosis: A study of 83 patients.
Harry Sokol
(1, 2)
,
Sophie Georgin-Lavialle
(3)
,
Danielle Canioni
(4)
,
Stéphane Barete
(5)
,
Gandhi Damaj
(6)
,
Erinn Soucie
(7)
,
Julie Bruneau
,
Marie-Olivia Chandesris
(8, 9, 10)
,
Felipe Suarez
(8, 9)
,
Jean-Marie Launay
(11)
,
Achille Aouba
(4)
,
Catherine Grandpeix-Guyodo
,
Fanny Lanternier
(12)
,
Bernard Grosbois
(13)
,
Christian de Gennes
,
Pascal Cathébras
,
Olivier Fain
(14)
,
Nadia Hoyeau-Idrissi
,
Patrice Dubreuil
(15, 16)
,
Olivier Lortholary
(17, 18)
,
Laurent Beaugerie
(1, 2)
,
Brigitte Ranque
(19)
,
Olivier Hermine
(8, 9)
1
UPMC -
Université Pierre et Marie Curie - Paris 6
2 CHU Saint-Antoine [AP-HP]
3 CHRI - Cytokines, hématopoïèse et réponse immune
4 Hôpital Necker - Enfants Malades [AP-HP]
5 CHU Tenon [AP-HP]
6 CHU Amiens-Picardie
7 CIML - Centre d'Immunologie de Marseille - Luminy
8 ERL 8254 - Equipe Inserm U1163 - Laboratory of molecular mechanisms of hematologic disorders and therapeutic implications
9 CEREDIH - Centre de Référence Déficits Immunitaires Héréditaires
10 Inserm U980 - Génétique Humaine des Maladies Infectieuses
11 Service Biochimie et Biologie Moleculaire
12 Centre d'infectiologie Necker-Pasteur [CHU Necker]
13 Service de Médecine interne et immunologie clinique [Rennes] = internal medicine and clinical immunology [Rennes]
14 service de médecine interne
15 CRCM - Centre de Recherche en Cancérologie de Marseille
16 AB Science
17 Département de Pédiatrie et maladies infectieuses [CHU Necker]
18 Equipe mobile d'infectiologie
19 UPD5 - Université Paris Descartes - Paris 5
2 CHU Saint-Antoine [AP-HP]
3 CHRI - Cytokines, hématopoïèse et réponse immune
4 Hôpital Necker - Enfants Malades [AP-HP]
5 CHU Tenon [AP-HP]
6 CHU Amiens-Picardie
7 CIML - Centre d'Immunologie de Marseille - Luminy
8 ERL 8254 - Equipe Inserm U1163 - Laboratory of molecular mechanisms of hematologic disorders and therapeutic implications
9 CEREDIH - Centre de Référence Déficits Immunitaires Héréditaires
10 Inserm U980 - Génétique Humaine des Maladies Infectieuses
11 Service Biochimie et Biologie Moleculaire
12 Centre d'infectiologie Necker-Pasteur [CHU Necker]
13 Service de Médecine interne et immunologie clinique [Rennes] = internal medicine and clinical immunology [Rennes]
14 service de médecine interne
15 CRCM - Centre de Recherche en Cancérologie de Marseille
16 AB Science
17 Département de Pédiatrie et maladies infectieuses [CHU Necker]
18 Equipe mobile d'infectiologie
19 UPD5 - Université Paris Descartes - Paris 5
Harry Sokol
- Fonction : Auteur
- PersonId : 801170
- IdHAL : harry-sokol
- ORCID : 0000-0002-2914-1822
- IdRef : 128516313
Sophie Georgin-Lavialle
- Fonction : Auteur
- PersonId : 764309
- IdHAL : sophie-georgin-lavialle
- ORCID : 0000-0001-6668-8854
- IdRef : 111766311
Julie Bruneau
- Fonction : Auteur
Felipe Suarez
- Fonction : Auteur
- PersonId : 758757
- ORCID : 0000-0002-3537-9052
Jean-Marie Launay
- Fonction : Auteur
- PersonId : 757247
- ORCID : 0000-0003-4809-1020
Catherine Grandpeix-Guyodo
- Fonction : Auteur
Christian de Gennes
- Fonction : Auteur
Pascal Cathébras
- Fonction : Auteur
Olivier Fain
- Fonction : Auteur
- PersonId : 1166060
- ORCID : 0000-0002-1974-3870
- IdRef : 069538476
Nadia Hoyeau-Idrissi
- Fonction : Auteur
Patrice Dubreuil
- Fonction : Auteur
- PersonId : 863869
Olivier Hermine
- Fonction : Auteur
- PersonId : 756140
- ORCID : 0000-0003-2574-3874
- IdRef : 069884927
Résumé
BACKGROUND: Mastocytosis is a heterogeneous disease characterized by mast cell accumulation in 1 or more organs. Gastrointestinal manifestations of systemic mastocytosis have been previously studied in small cohorts of patients, and no specific histologic description is available. OBJECTIVE: We sought to assess the clinical and pathologic features of gastrointestinal manifestations in patients with mastocytosis. METHODS: Medical history and gastrointestinal symptoms of patients with mastocytosis (n = 83) were compared with those of matched healthy subjects (n = 83) by means of patient questionnaire. Data were analyzed for epidemiologic, clinical, biological, and genetic factors associated with gastrointestinal symptoms for patients with mastocytosis. A comparative analysis of gastrointestinal histology from patients with mastocytosis (n = 23), control subjects with inflammatory bowel disease (n = 17), and healthy subjects (n = 19) was performed. RESULTS: The following gastrointestinal symptoms occurred more frequently and were more severe in patients with mastocytosis than in healthy subjects: bloating (33% vs 7.2%, P < .0001), abdominal pain (27.3% vs 4.8%, P < .0001), nausea (23% vs 8.4%, P = .02), and diarrhea (33.85% vs 1.2%, P < .0001). Patients with mastocytosis had a significantly higher incidence of personal history of duodenal ulcer (P = .02). Wild-type (WT) c-Kit was associated with diarrhea (P = .03). Specific histologic lesions were present in patients with mastocytosis but were not correlated with clinical symptoms. CONCLUSION: Gastrointestinal manifestations in patients with mastocytosis are highly prevalent and often severe. Clinical symptoms do not correspond to histologic findings, are nonspecific, and can simulate irritable bowel syndrome.
Domaines
Chimie organiqueFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Résumé |
en
BACKGROUND: Mastocytosis is a heterogeneous disease characterized by mast cell accumulation in 1 or more organs. Gastrointestinal manifestations of systemic mastocytosis have been previously studied in small cohorts of patients, and no specific histologic description is available. OBJECTIVE: We sought to assess the clinical and pathologic features of gastrointestinal manifestations in patients with mastocytosis. METHODS: Medical history and gastrointestinal symptoms of patients with mastocytosis (n = 83) were compared with those of matched healthy subjects (n = 83) by means of patient questionnaire. Data were analyzed for epidemiologic, clinical, biological, and genetic factors associated with gastrointestinal symptoms for patients with mastocytosis. A comparative analysis of gastrointestinal histology from patients with mastocytosis (n = 23), control subjects with inflammatory bowel disease (n = 17), and healthy subjects (n = 19) was performed. RESULTS: The following gastrointestinal symptoms occurred more frequently and were more severe in patients with mastocytosis than in healthy subjects: bloating (33% vs 7.2%, P < .0001), abdominal pain (27.3% vs 4.8%, P < .0001), nausea (23% vs 8.4%, P = .02), and diarrhea (33.85% vs 1.2%, P < .0001). Patients with mastocytosis had a significantly higher incidence of personal history of duodenal ulcer (P = .02). Wild-type (WT) c-Kit was associated with diarrhea (P = .03). Specific histologic lesions were present in patients with mastocytosis but were not correlated with clinical symptoms. CONCLUSION: Gastrointestinal manifestations in patients with mastocytosis are highly prevalent and often severe. Clinical symptoms do not correspond to histologic findings, are nonspecific, and can simulate irritable bowel syndrome.
|
Titre |
en
Gastrointestinal manifestations in mastocytosis: A study of 83 patients.
|
Auteur(s) |
Harry Sokol
1, 2
, Sophie Georgin-Lavialle
3
, Danielle Canioni
4
, Stéphane Barete
5
, Gandhi Damaj
6
, Erinn Soucie
7
, Julie Bruneau
, Marie-Olivia Chandesris
8, 9, 10
, Felipe Suarez
8, 9
, Jean-Marie Launay
11
, Achille Aouba
4
, Catherine Grandpeix-Guyodo
, Fanny Lanternier
12
, Bernard Grosbois
13
, Christian de Gennes
, Pascal Cathébras
, Olivier Fain
14
, Nadia Hoyeau-Idrissi
, Patrice Dubreuil
15, 16
, Olivier Lortholary
17, 18
, Laurent Beaugerie
1, 2
, Brigitte Ranque
19
, Olivier Hermine
8, 9
1
UPMC -
Université Pierre et Marie Curie - Paris 6
( 93591 )
- 4 place Jussieu - 75005 Paris
- France
2
CHU Saint-Antoine [AP-HP]
( 454982 )
- 184, rue du Faubourg Saint-Antoine
75571 Paris cedex 12
- France
3
CHRI -
Cytokines, hématopoïèse et réponse immune
( 1288 )
- Bâtiment Sèvres - Porte I
161 Rue de Sèvres
75743 PARIS CEDEX 15
- France
4
Hôpital Necker - Enfants Malades [AP-HP]
( 414766 )
- 149 Rue de Sèvres 75015 Paris
- France
5
CHU Tenon [AP-HP]
( 328304 )
- 4 Rue de la Chine, 75020 Paris
- France
6
CHU Amiens-Picardie
( 300535 )
- France
7
CIML -
Centre d'Immunologie de Marseille - Luminy
( 182245 )
- Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09
- France
8
ERL 8254 - Equipe Inserm U1163 -
Laboratory of molecular mechanisms of hematologic disorders and therapeutic implications
( 88548 )
- 24, Boulevard de Montparnasse
75015 PARIS
- France
9
CEREDIH -
Centre de Référence Déficits Immunitaires Héréditaires
( 80990 )
- 149, rue de Sevres 75015 PARIS
- France
10
Inserm U980 -
Génétique Humaine des Maladies Infectieuses
( 2909 )
- Fac de Medecine Necker-Enfants Malades
156, Rue de Vaugirard
75730 PARIS CEDEX 15
- France
11
Service Biochimie et Biologie Moleculaire
( 111179 )
- Hopital Lariboisiere, F-75475 Paris
- France
12
Centre d'infectiologie Necker-Pasteur [CHU Necker]
( 181780 )
- Service des Maladies infectieuses et Tropicales
Bâtiment Jean Hamburger
149 rue de Sèvres
75015 Paris
- France
13
Service de Médecine interne et immunologie clinique [Rennes] = internal medicine and clinical immunology [Rennes]
( 24767 )
- CHU Rennes
- France
14
service de médecine interne
( 212051 )
- France
15
CRCM -
Centre de Recherche en Cancérologie de Marseille
( 179570 )
- 27 bd Leï Roure, BP 300059
13273 Marseille Cedex 09
- France
16
AB Science
( 204693 )
- 3 avenue George V 75008 Paris
- France
17
Département de Pédiatrie et maladies infectieuses [CHU Necker]
( 463209 )
- 149 Rue de Sèvres, 75015 Paris
- France
18
Equipe mobile d'infectiologie
( 223393 )
- Equipe mobile d'infectiologie, Hôpital Necker-Enfants Malades, Paris, France
- France
19
UPD5 -
Université Paris Descartes - Paris 5
( 301664 )
- 12, rue de l'École de Médecine - 75270 Paris cedex 06
- France
|
Volume |
132
|
Date de publication |
2013-07-25
|
Audience |
Internationale
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Numéro |
4
|
Page/Identifiant |
866–873.e3
|
Public visé |
Scientifique
|
Domaine(s) |
|
Financement |
|
Mots-clés |
en
Mastocytosis, c-Kit, MAST-CELL DISEASE, KIT MUTATION, DISORDERS, ABNORMALITIES, INVOLVEMENT, ACTIVATION, TRYPTASE
fr
mast cells, gastrointestinal tract, SYSTEMIC MASTOCYTOSIS, LEUKEMIA, MALABSORPTION
|
DOI | 10.1016/j.jaci.2013.05.026 |
ProdINRA | 219412 |
Pubmed Id | 23890756 |
UT key WOS | 000325096500013 |
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