Synchrotron radiation micro-CT imaging of the mouse brain
Résumé
Purpose: MRI coupled with the injection of ultrasmall particles of iron oxide (US-PIO) has been successfully applied for pre-clinical and clinical studies of cerebral inflammation following stroke. Current limitations of this approach are represented by the difficulty of interpreting MR signal changes in terms of exact USPIO localisation. To overcome this limitation, we introduce Synchrotron Radiation phase micro-computerized tomography (SR-PCT) as a new method to visualise USPIO distribution into the whole brains of mice with cerebral ischaemia.