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Article Dans Une Revue Chemical Society Reviews Année : 2008

Functionalization of diazines and benzo derivatives through deprotonated intermediates.

Résumé

This critical review targets as a readership researchers generally oriented toward organic synthesis and in particular those active in heterocyclic chemistry. Diazines and benzo derivatives can undergo deprotonative metalation provided that the base is properly chosen. Metalation reactions of a large range of substrates can be performed using hindered lithium dialkylamides such as lithium 2,2,6,6-tetramethylpiperidide. Subsequent reactions with electrophiles open an entry to a great variety of building blocks, notably for the synthesis of biologically active compounds. (83 references).

Domaines

Chimie organique
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Dates et versions

hal-00842708 , version 1 (06-06-2014)

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Floris Chevallier, Florence Mongin. Functionalization of diazines and benzo derivatives through deprotonated intermediates.. Chemical Society Reviews, 2008, 37 (3), pp.595-609. ⟨10.1039/b709416g⟩. ⟨hal-00842708⟩
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