Mannose-functionalized porous silica-coated magnetic nanoparticles for two-photon imaging or PDT of cancer cells - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Nanoparticle Research Année : 2013

Mannose-functionalized porous silica-coated magnetic nanoparticles for two-photon imaging or PDT of cancer cells

Olivier Mongin

Résumé

An original fluorophore engineered for two-photon excitation or a porphyrin derivative were entrapped in the silica shell of magnetic porous silica nanoparticles during the synthesis of the silica moiety without damaging the structure of the organic part. The mild conditions involved allowed obtaining microporous or mesoporous silica magnetic nanoparticles, respectively. Mannose was grafted on the surface of the nanoparticles to target MCF-7 breast cancer cells. The studies of magnetic properties of these hybrid nanoparticles showthat they present a blocking temperature at 190 K. The nano-objects designed with the twophoton fluorophore were efficient for two-photon imaging of MCF-7 cancer cells, whereas the nanoobjects with the photosensitizer efficiently killed cancer cells. The presence of the mannose moiety was demonstrated to improve both imaging and therapy properties.

Domaines

Chimie organique

Dates et versions

hal-00841213 , version 1 (04-07-2013)

Identifiants

Citer

Marine Perrier, Magali Gary-Bobo, Lenaic Lartigue, David Brevet, Alain Morère, et al.. Mannose-functionalized porous silica-coated magnetic nanoparticles for two-photon imaging or PDT of cancer cells. Journal of Nanoparticle Research, 2013, 15, pp.1602-1609. ⟨10.1007/s11051-013-1602-9⟩. ⟨hal-00841213⟩
277 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More