Let V be a two-dimensional absolutely irreducible p-adic Galois representation and let Pi be the p-adic Banach space representation associated to V via Colmez's p-adic Langlands correspondence. We establish a link between the infinitesimal action of GL_2(Q_p) on the locally analytic vectors of Pi, the differential equation associated to V via the theory of Fontaine and Berger, and the Sen polynomial of V. This answers a question of Harris and gives a new proof of a theorem of Colmez: Pi has nonzero locally algebraic vectors if and only if V is potentially semi-stable with distinct Hodge-Tate weights.