New tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic properties. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Dalton Transactions Année : 2013

New tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic properties.

Andrea Melchior
  • Fonction : Auteur
Sérgio M Marques
  • Fonction : Auteur
Sílvia Chaves
  • Fonction : Auteur
Sandrine Villette
  • Fonction : Auteur
  • PersonId : 875214
Stéphane Petoud
Pier Luigi Zanonato
  • Fonction : Auteur
Marilena Tolazzi
  • Fonction : Auteur
Célia S Bonnet
Éva Tóth
Plinio Di Bernardo
  • Fonction : Auteur
Carlos F G C Geraldes
  • Fonction : Auteur
M Amélia Santos
  • Fonction : Auteur

Résumé

There is a growing interest in the development of new medical diagnostic tools with higher sensibility and less damage for the patient body, namely on imaging reporters for the management of diseases and optimization of treatment strategies. This article examines the properties of a new class of lanthanide complexes with a tripodal tris-3-hydroxy-4-pyridinone (tris-3,4-HOPO) ligand - NTP(PrHP)3. Among the studies herein performed, major relevance is given to the thermodynamic stability of the complexes with a series of Ln(3+) ions (Ln = La, Pr, Gd, Er, Lu) and to the magnetic relaxation properties of the Gd(3+) complex. This hexadentate ligand enables the formation of (1 : 1) Ln(3+) complexes with high thermodynamic stability following the usual trend, while the Gd-chelates show improved relaxivity (higher hydration number), as compared with the commercially available Gd-based contrast agents (CAs); transmetallation of the Gd(3+)-L complex with Zn(2+) proved to be thermodynamically and kinetically disfavored. Therefore, NTP(PrHP)3 emerges as part of a recently proposed new generation of CAs with prospective imaging sensibility gains.
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Dates et versions

hal-00817499 , version 1 (24-04-2013)

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Citer

Ana Catarina Fernandes Mendonça, André F Martins, Andrea Melchior, Sérgio M Marques, Sílvia Chaves, et al.. New tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic properties.. Dalton Transactions, 2013, 42 (17), pp.6046-57. ⟨10.1039/c2dt32237d⟩. ⟨hal-00817499⟩
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