Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2012

Virulence factors and TEM-type β-lactamases produced by two isolates of an epidemic Klebsiella pneumoniae strain.

Résumé

Two Klebsiella pneumoniae isolates of the same strain, identified in Poland, produced either TEM-47 or TEM-68, which differed by the Arg275Leu substitution. They harbored a few virulence factors, including an iron-chelating factor and capsule overproduction, suggesting that these factors were sufficient to enhance their nosocomial potency. TEM-68 and TEM-47 had similar enzymatic activities, but TEM-68 was less susceptible to inhibitors than TEM-47. These results confirm the role of the Arg275Leu substitution in the evolution of TEM enzymes.

Dates et versions

hal-00815978 , version 1 (19-04-2013)

Identifiants

Citer

Frédéric Robin, Claire Hennequin, Marek Gniadkowski, Racha Beyrouthy, Joanna Empel, et al.. Virulence factors and TEM-type β-lactamases produced by two isolates of an epidemic Klebsiella pneumoniae strain.. Antimicrobial Agents and Chemotherapy, 2012, 56 (2), pp.1101-4. ⟨10.1128/AAC.05079-11⟩. ⟨hal-00815978⟩
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