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Article Dans Une Revue Biochemical Journal Année : 1984

Binding of a spin-labelled chlorpromazine analogue to calmodulin.

D. Rainteau
C. Wolf
J. Polonovski
  • Fonction : Auteur

Résumé

The binding of a spin-labelled derivative of chlorpromazine to calmodulin was investigated by e.s.r. spectrometry. The completion of the spectroscopic changes requires the presence of 4 Ca2+ ions per calmodulin molecule. The influences of various physicochemical factors (pH, ionic strength) are discussed in relation to the nature (hydrophobic and polar) of the interactions that hold the drug-calmodulin complex together.

Domaines

Chimie organique
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Dates et versions

hal-00813749 , version 1 (16-04-2013)

Identifiants

  • HAL Id : hal-00813749 , version 1
  • PUBMED : 6089743

Citer

D. Rainteau, C. Wolf, G. Bereziat, J. Polonovski. Binding of a spin-labelled chlorpromazine analogue to calmodulin.. Biochemical Journal, 1984, 221 ((3)), pp.659-63. ⟨hal-00813749⟩
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