Article Dans Une Revue Physica Status Solidi C: Current Topics in Solid State Physics Année : 2010

Matrix metalloproteinase sensing via porous silicon microcavity devices functionalized with human antibodies

Marta Martin
Chakib Taleb Bendiab
  • Fonction : Auteur
Laurent Massif
  • Fonction : Auteur
Vivechana Agarwal
  • Fonction : Auteur
Csilla Gergely

Résumé

Porous silicon microcavity (PSiMc) structures were used as support material for specific sensing of matrix metal- loproteinases (MMPs). For lower concentrations of MMP-8, the structures were tested with two types of functionalization methods. Silanization of the oxidized porous silicon structures, followed by glutaraldehyde chemistry was found to give very inconsistent results. The use of biotinilated bovin serum albumin linked to the naked PSiMc was found to be an alternative method to attach the anti MMP-8 human antibody, previously modi- fied with streptavidin, which was further used to sense MMP-8.

Dates et versions

hal-00812532 , version 1 (12-04-2013)

Identifiants

Citer

Marta Martin, Chakib Taleb Bendiab, Laurent Massif, Gabriela Palestino, Vivechana Agarwal, et al.. Matrix metalloproteinase sensing via porous silicon microcavity devices functionalized with human antibodies. Physica Status Solidi C: Current Topics in Solid State Physics, 2010, C8 (6), pp.1888. ⟨10.1002/pssc.201000155⟩. ⟨hal-00812532⟩
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