Biocidal activity of metalloacid-coated surfaces against multidrug-resistant microorganisms. - Archive ouverte HAL Access content directly
Journal Articles Antimicrob Resist Infect Control Year : 2012

Biocidal activity of metalloacid-coated surfaces against multidrug-resistant microorganisms.


UNLABELLED: BACKGROUND: The antimicrobial effects of a coating of molybdenum trioxide (MoO3) has been recently described. The metalloacid material produces oxonium ions (H3O+), which creates an acidic pH that is an effective, non specific antimicrobial. We determined the in vitro antimicrobial activity of molybdenum trioxide metalloacid-coated surfaces. METHODS: Metalloacid-coated and non-coated (control) surfaces were contaminated by exposing them for 15 minutes to microbial suspensions containing 105 cfu/mL. Eleven microorganisms responsible for nosocomial infections were tested: two Staphylococcus aureus strains (the hetero-vancomycin intermediate MRSA Mu50 strain and a ST80-PVL-producing MRSA strain); a vancomycin-resistant vanA Enterococcus faecium strain; three extended-spectrum beta-lactamase-producing Enterobacteriaceae strains; a MBL-producing Pseudomonas aeruginosa strain; a multidrug-resistant Acinetobacter baumannii strain; a toxin-producing Clostridium difficile strain; and two fungi (Candida albicans and Aspergillus fumigatus). The assay tested the ability of the coated surfaces to kill microorganisms. RESULTS: Against all non-sporulating microorganisms tested, metalloacid-coated surfaces exhibited significant antimicrobial activity relative to that of the control surfaces within two to six hours after contact with the microorganisms (p < 0.001). Microorganism survival on the coated surfaces was greatly impaired, whereas microorganism survival on control surfaces remained substantial. CONCLUSIONS: We suggest that, facing the continuing shedding of microorganisms in the vicinity of colonized or infected patients, the continuous biocidal effect of hydroxonium oxides against multidrug-resistant microorganisms may help limit environmental contamination between consecutive cleaning procedures.
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hal-00802751 , version 1 (29-05-2020)


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Nathalie Tétault, Houssein Gbaguidi-Haore, Xavier Bertrand, Roland Quentin, Nathalie van Der Mee-Marquet. Biocidal activity of metalloacid-coated surfaces against multidrug-resistant microorganisms.. Antimicrob Resist Infect Control, 2012, 1 (1), pp.35. ⟨10.1186/2047-2994-1-35⟩. ⟨hal-00802751⟩
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