Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Bioorganic and Medicinal Chemistry Année : 2011

Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents.

Résumé

A collection of 3-substituted indole derivatives was prepared using nucleophilic addition of indoles to nitrones. The compounds were then tested for their antibacterial activity against almost thirty bacterial strains representative of common human pathogens. Two types of indolic molecules inhibit the growth of Staphylococcus aureus, including MRSA and VISA strains, with MIC values ranging from 8 to 16 mg/L.

Dates et versions

hal-00801247 , version 1 (15-03-2013)

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Olga N Burchak, Emmanuelle Le Pihive, Laure Maigre, Xavier Guinchard, Pascale Bouhours, et al.. Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents.. Bioorganic and Medicinal Chemistry, 2011, 19 (10), pp.3204-15. ⟨10.1016/j.bmc.2011.03.060⟩. ⟨hal-00801247⟩
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