In this paper, a three-phase drive with a six-leg Voltage Source Inverter (VSI) and an open-end winding Interior Permanent Magnet Synchronous Machine (IPMSM) designed for the traction of an electric vehicle is studied in flux-weakening operation. The topology allows the functionality of a high power charger to be obtained, without adding any other supplementary power devices. On the other hand, since there are three independent currents, the control structure has to handle not only the two dq current components but also a zero-sequence current. If neglected, in comparison with wye-coupled three-phase drive, this zero-sequence component can cause a higher maximum peak value of the phase currents, additional stator Joule losses, torque ripple, inverter voltage saturation and IGBT oversizing. The proposed control strategy consists in adapting a conventional method used for wye-connected machines particularly in flux-weakening operation. This strategy allows the closed-loop control of the zero-sequence current to be maintained in the whole speed range and therefore inverter saturation is avoided. Simulations and experimental results are presented and analyzed.