Plant-specific multisubunit RNA polymerase in gene silencing. - Archive ouverte HAL Access content directly
Journal Articles Epigenetics Year : 2010

Plant-specific multisubunit RNA polymerase in gene silencing.


In recent years, a major breakthrough in the study of epigenetic silencing in eukaryotes came with the discovery that the RNA-interference pathway (RNAi) is generally implicated in heterochromatin assembly and gene silencing. An important and paradoxical feature of the RNAi-mediated heterochromatin pathways is their requirement for some form of transcription. In fission yeast, Schizosaccharomyces pombe, centromeric siRNAs have been shown to derive from chromatin-bound nascent transcripts produced by RNA polymerase II (PolII) at the site of heterochromatin formation. Likewise, chromatin-bound nascent transcripts generated by a PolII-related DNA-dependent RNA polymerase, known as PolIVb/PolV, have recently been implicated in RNA-directed DNA methylation (RdDM), the prominent RNAi-mediated chromatin pathway in plants. In this review we discuss recent work on the plant-specific PolII variant enzymes and discuss the mechanistic convergences that have been observed in the role of these enzymes in their respective siRNA-mediated heterochromatin formation pathways.
Not file

Dates and versions

hal-00788114 , version 1 (13-02-2013)


  • HAL Id : hal-00788114 , version 1
  • PUBMED : 20173420


Sylvie Lahmy, Natacha Bies-Etheve, Thierry Lagrange. Plant-specific multisubunit RNA polymerase in gene silencing.. Epigenetics, 2010, 5 (1), pp.4-8. ⟨hal-00788114⟩
82 View
0 Download



Gmail Facebook Twitter LinkedIn More