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Article Dans Une Revue Journal of the American Chemical Society Année : 2012

Biologically Active Polymersomes from Amphiphilic Glycopeptides

Résumé

Polypeptide block copolymers with different block length ratios were obtained by sequential ring-opening polymerization of benzyl-L-glutamate and propargylglycine (PG) N-carboxyanhydrides. Glycosylation of the poly(PG) block was obtained by Huisgens cycloaddition "click" reaction using azide-functionalized galactose. All copolymers were self-assembled using the nanoprecipitation method to obtain spherical and wormlike micelles as well as polymersomes depending on the block length ratio and the nanoprecipitation conditions. These structures display bioactive galactose units in the polymersome shell, as proven by selective lectin binding experiments.
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Dates et versions

hal-00757517 , version 1 (27-11-2012)

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Jin Huang, Colin Bonduelle, Julie Thevenot, Sébastien Lecommandoux, Andreas Heise. Biologically Active Polymersomes from Amphiphilic Glycopeptides. Journal of the American Chemical Society, 2012, 134 (1), pp.119-122. ⟨10.1021/ja209676p⟩. ⟨hal-00757517⟩

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