Residues of sulfadiazine and doxycycline in broiler liver and muscle tissues due to cross-contamination in the feed
Résumé
Veterinary drugs, such as antimicrobial compounds are widely used in poultry and may lead to the presence of residues in matrices of animal origin such as muscle and liver tissue. In this study, broilers received experimental feed, containing sulfadiazine or doxycycline at cross contamination levels of 2.5%, 5% and 10 % of the therapeutic dose in feed. Breast- and thigh muscle and liver samples were collected during treatment and depletion period and analyzed via liquid chromatography-tandem mass spectrometry (LC-MS/MS). Concentrations reached a plateau phase 3 to 5 days after starting the experimental feed. A rapid depletion of residues was noted after withdrawal of the experimental feed. No significant differences in measured concentrations were observed between the different muscle types. The residue concentrations for some experimental groups, the 10 % group of sulfadiazine and the 5% and 10 % group of doxycycline, however exceeded the corresponding Maximum Residue Limits (MRLs).
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