Studies of a furanoside as antimycobacterial agent loaded into a biodegradable PBAT/sodium caseinate support.
Résumé
An improved synthesis of n-octyl β-D-galactofuranoside was described using micro-wave activation. The resulting alkyl furanoside showed antibacterial activity against Mycobacterium smegmatis, a non-pathogenic model of Mycobacterium tuberculosis. It was further incorporated into a biodegradable PBAT/sodium caseinate polymer. The resulting biomaterial loaded with 5% of the pharmacophore retained the mycobacteriostatic properties and developed a mycobactericidal activity on contact and at the periphery of the film.
Mots clés
Anti-Bacterial Agents/chemical synthesis
Anti-Bacterial Agents/pharmacology
Antifungal Agents/chemical synthesis
Antifungal Agents/pharmacology
Biodegradation
Environmental
Caseins/chemistry
Chromatography
Gel
Furans/chemical synthesis
Furans/pharmacology
Glucosides/chemical synthesis
Glucosides/pharmacology
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Microwaves
Mycobacterium Infections
Nontuberculous/microbiology
Mycobacterium smegmatis*/drug effects
Mycobacterium smegmatis*/growth & development
Mycobacterium tuberculosis
Polyesters/chemistry