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Article Dans Une Revue Current Protein and Peptide Science Année : 2012

Membrane Interacting Peptides: From Killers to Helpers.

Résumé

Membrane interacting peptides are reviewed in terms of structure and mode of action on lipid membranes. Helical, β-stranded, peptides containing both helices and strands, cyclic, lipopeptides and short linear peptides are seen to considerably modulate membrane function. Among peptides that lead to membrane alteration or permeation, antimicrobial peptides play an important role and some of them may be foreseen as potential new antibiotics. Alternatively, peptides that do not destroy the membrane are also very important in modulating the structure and dynamics of the lipid bilayer and play important roles in membrane protein functions. Peptide lipid complexes are shown to be very variable in structure and dynamics: "carpet", "barrel stave", toroid and disordered pores, electrostatic wedge and molecular electroporation models are discussed. Their assembly is reviewed in terms of electric, amphipathic and dynamic properties of both lipids and peptides.

Domaines

Chimie organique
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Dates et versions

hal-00748185 , version 1 (05-11-2012)

Identifiants

Citer

Erick J Dufourc, Sébastien Buchoux, Jeannot Toupé, Marc-Antoine Sani, Frantz Jean-François, et al.. Membrane Interacting Peptides: From Killers to Helpers.. Current Protein and Peptide Science, 2012, 13 (7), pp.620-631. ⟨10.2174/138920312804142138⟩. ⟨hal-00748185⟩
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