Deletion and dosage modulation of the eEF1A gene in Podospora anserina: effect on the life cycle. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biogerontology Année : 2000

Deletion and dosage modulation of the eEF1A gene in Podospora anserina: effect on the life cycle.

Résumé

eEF1A is encoded by a unique gene in the filamentous fungus Podospora anserina. We show here that (1) this gene is essential for vegetative growth, (2) readthrough at UGA stop codon level is positively correlated with eEF1A level, (3) eEF1A level is regulated in P. anserina. (4) Increasing eEF1A gene dosage does not modify P. anserina life cycle parameters, especially longevity is not changed. These data confirm and extend those previously obtained in yeast and Drosophila.
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Dates et versions

hal-00741893 , version 1 (15-10-2012)

Identifiants

  • HAL Id : hal-00741893 , version 1
  • PUBMED : 11707920

Citer

P. Silar, M. Rossignol, V. Haedens, Z. Derhy, André Mazabraud. Deletion and dosage modulation of the eEF1A gene in Podospora anserina: effect on the life cycle.. Biogerontology, 2000, 1 (1), pp.47-54. ⟨hal-00741893⟩
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