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Article Dans Une Revue Amino Acids Année : 2012

Resolution of protected silaproline for a gram scale preparation

Résumé

Silaproline is an analogue of proline, which exhibits similar conformational properties. Moreover, the presence of dimethylsilyl group confers to silaproline a higher lipophilicity as well as an improved resistance to biodegradation. This report describes the comparison of two routes to obtain Fmoc-(L) Sip-OH on the gram scale using chiral HPLC resolution.

Domaines

Chimie organique

Dates et versions

hal-00724765 , version 1 (22-08-2012)

Identifiants

Citer

C. Martin, N. Vanthuyne, H. Miramon, J. Martinez, F. Cavelier. Resolution of protected silaproline for a gram scale preparation. Amino Acids, 2012, 43, pp.649-655. ⟨10.1007/s00726-011-1112-y⟩. ⟨hal-00724765⟩
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