Dietary n-3 polyunsaturated fatty acid deprivation together with early maternal separation increases anxiety and vulnerability to stress in adult rats. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Prostaglandins, Leukotrienes and Essential Fatty Acids Année : 2011

Dietary n-3 polyunsaturated fatty acid deprivation together with early maternal separation increases anxiety and vulnerability to stress in adult rats.

Résumé

Low concentrations of n-3 polyunsaturated fatty acid (PUFA) and chronic stress are implicated in susceptibility to mood disorders. We have investigated the combined effects of chronic n-3 PUFA dietary deficiency and early maternal separation (MS) stress on the reactivity to stressful situations of rats as adults. Pups fed a control or an n-3 PUFA deficient diet were daily separated for two weeks before weaning They were all tested at 3 month-old to determine their anxiety, and their ability to learn two aversive tasks differing in the control they could exert on the situation: auditory fear conditioning and brightness avoidance discrimination. Neither the n-3 PUFA-deficient diet nor MS alone significantly affected behavior. But n-3 PUFA-deficient rats that had been separated were more anxious and fearful in inescapable situations, while their ability to cope with an aversive avoidance task remained unaffected. These results support the notion that PUFA-unbalanced diet, together with stress, may be a determinant risk factor in emotional disorders.

Dates et versions

hal-00717827 , version 1 (13-07-2012)

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Citer

Géraldine Mathieu, Catherine Oualian, Isabelle Denis, Monique Lavialle, Pascale Gisquet-Verrier, et al.. Dietary n-3 polyunsaturated fatty acid deprivation together with early maternal separation increases anxiety and vulnerability to stress in adult rats.. Prostaglandins, Leukotrienes and Essential Fatty Acids, 2011, 85 (3-4), pp.125-136. ⟨10.1016/j.plefa.2011.07.001⟩. ⟨hal-00717827⟩
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