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Communication Dans Un Congrès Eprints@NML Année : 2011

On the existence of a dynamic critical point by using wet milling on (±) modafinil

Julie Linol
  • Fonction : Auteur
Pauline Martinetto
Michel Anne
  • Fonction : Auteur
  • PersonId : 872577
G. Coquerel

Résumé

This study has been carried out on the molecular compound (±) modafinil, which exhibits five pure polymorphic forms (I, III, IV, V and VI). At P = 1 atm, irrespective of temperature and without any milling energy, Form I is the stable form. Therefore, the other polymorphic forms (III, IV, V and VI) are of monotropic character. The steady states of (±) modafinil have been investigated as a function of wet milling parameters (milling intensity and water concentration). The results presented here suggest the existence of a dynamic critical point defined by Tc ≈ 40°C, Pc ≈ 1 atm, Ic ≈ k R; R=50, Xc = 2% mass percent of water, respectively the critical: mean temperature, global pressure, milling intensi
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Dates et versions

hal-00717768 , version 1 (13-07-2012)

Identifiants

  • HAL Id : hal-00717768 , version 1

Citer

Julie Linol, Pauline Martinetto, Michel Anne, G. Coquerel. On the existence of a dynamic critical point by using wet milling on (±) modafinil. VI International Conference on Mechanochemistry and Mechanical Alloying, Dec 2008, Jamshedpur, India. ⟨hal-00717768⟩

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