Nanoaggregates of biodegradable amphiphilic random polycations for delivering water-insoluble drugs. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biomacromolecules Année : 2012

Nanoaggregates of biodegradable amphiphilic random polycations for delivering water-insoluble drugs.

Résumé

Cationic amphiphilic random copolyesters were obtained by copolymerization of 5-Z-amino-δ-valerolactone and ε-caprolactone. The amino content of the final copolymers was controlled by the polymerization feed ratio and was in the range 10 to 100%. Copolymers solubility and aggregation behavior was assessed by conductometric and zeta potential analyses. A critical aggregation concentration of ca. 0.05% (w/v) was found for all water-soluble copolymers that formed nanoaggregates. Two populations were found to be present in equilibrium with hydrodynamic diameters in the range of 30-50 and 100-250 nm. The capacity to use the amphiphilic and cationic character of the nanoaggregates to encapsulate highly hydrophobic compounds was further investigated. Finally, copolymers hemo- and cytocompatibility were evaluated by hemagglutination, hemolysis, and cells proliferation tests. The results showed that the proposed cationic amphiphilic random copolyesters are biocompatible.

Domaines

Chimie organique
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Dates et versions

hal-00717296 , version 1 (12-07-2012)

Identifiants

Citer

Benjamin Nottelet, Manuela Patterer, Benjamin François, Marc -Alexandre Schott, Martine Domurado, et al.. Nanoaggregates of biodegradable amphiphilic random polycations for delivering water-insoluble drugs.. Biomacromolecules, 2012, 13 (5), pp.1544-53. ⟨10.1021/bm300251j⟩. ⟨hal-00717296⟩
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