Synthesis of secondary 2-amino thiols and/or their disulfides via thiazolinium salts
Résumé
Commercially available β-amino alcohols have been transformed into various secondary β-amino thiols and/or their disulfides by using methyl dithioacetate as a source of sulfur. The transformation involves a thiazolinium salt as a versatile key intermediate, which enables easy modulation of the product structure by varying the substituents on the heterocycle and the N-alkylating agent.