A water soluble Cu-I-NHC for CuAAC ligation of unprotected peptides under open air conditions. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2012

A water soluble Cu-I-NHC for CuAAC ligation of unprotected peptides under open air conditions.

Résumé

A reducing agent-free version of CuAAC able to operate under open air conditions is reported. A readily-synthesizable, hydrophilic and highly stable CuI-NHC allows the clean ligations of unprotected peptides comprising sensitive side chains, at millimolar concentrations.
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Dates et versions

hal-00711780 , version 1 (25-06-2012)

Identifiants

  • HAL Id : hal-00711780 , version 1

Citer

Christelle Gaulier, Audrey Hospital, Bertrand Legeret, Delmas A.F., Vincent Aucagne, et al.. A water soluble Cu-I-NHC for CuAAC ligation of unprotected peptides under open air conditions.. Chemical Communications, 2012, 48, pp.4005-4007. ⟨hal-00711780⟩
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