Mathematical modeling of pulmonary tuberculosis therapy: insights from a prototype model with rifampin
Résumé
There is a critical need for improved and shorter tuberculosis (TB) treatment. Current models of TB, while valuable, are poor predictors of the antibacterial effect of drugs . Mathematical models may be useful to overcome the limitations of traditional approaches in TB research. The objective of this study was to set up a prototype mathematical model of TB treatment by rifampin, based on pharmacokinetic, pharmacodynamic and disease submodels.
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