This paper presents a technique for generating orthogonal bases of signals with jointly optimized spectra, in the sense that they are made as close as possible. To this end, we propose a new criterion, the minimization of which leads to signals with close energy inside a set of prescribed subbands. Starting with the case of a single subband, we illustrate it by building orthogonal signals with maximum energy concentration in time and in frequency, with the same energy rate outside a fixed frequency interval or a fixed time interval, by resorting to Slepian sequences or Slepian functions, respectively. Then, we present spectrum balancing in a set of frequency intervals. We apply this method to Slepian sequences and Slepian functions, as well as to Walsh–Hadamard codes. On these examples, we point out a number of nice properties of the so-built orthogonal families that are of interest for signaling applications.