Evaluation of urinary biomarkers of oxidative/nitrosative stress in adolescents and adults with Down syndrome
Résumé
Urinary biomarkers of oxidative stress have been little studied in adults with Down syndrome (DS), usually no more than two biomarkers have been measured in the population studied and controversial results are reported in literature. Thus, we aimed to assess a set of oxidative and nitrosative stress biomarkers in urine samples of adolescents and adults with DS, with and without hypothyroidism, which comprise: 8-hydroxy-2'-deoxyguanosine (8-OHdG), isoprostane 15-F-IsoP, thiobarbituric acid-reacting substances (TBARS), advanced glycation end products (AGEs), dityrosine (diTyr), hydrogen peroxide (HO) and nitrite/nitrate (NOx). Fluorimetric and spectrophotometric assays were performed in DS (=78), some of them taking levothyroxine for hypothyroidism (=24), and in their healthy age-matched controls (=65).
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