Second generation specific-enzyme-activated rotaxane propeptides. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2012

Second generation specific-enzyme-activated rotaxane propeptides.

Résumé

A [2]rotaxane, in which the peptidic axle is protected from degradation by the macrocyclic sheath and terminated with a novel glycosidase-cleavable stopper, is rendered water-soluble by derivatisation with tetra(ethylene glycol) (TetEG) or glucosylated tetra(ethylene glycol) (Glc-TetEG) chains using the CuAAC 'click' reaction. The Glc-TetEG-derivatised rotaxane propeptide is >50 000 times more soluble in aqueous media than the parent rotaxane. Activation of the water-soluble rotaxane propeptide with a β-galactosidase efficiently releases the parent peptide.
Fichier non déposé

Dates et versions

hal-00678757 , version 1 (13-03-2012)

Identifiants

Citer

Antony Fernandes, Aurélien Viterisi, Vincent Aucagne, David A Leigh, Sébastien Papot. Second generation specific-enzyme-activated rotaxane propeptides.. Chemical Communications, 2012, 48 (15), pp.2083-5. ⟨10.1039/c2cc17458h⟩. ⟨hal-00678757⟩
57 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More