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Article Dans Une Revue Molecular Psychiatry Année : 2011

An Aetiological Mutation Causes Aberrant Striatal Activity and Alters Plasticity during Skill Learning

Résumé

Mutations in the human gene cause impaired speech development and linguistic deficits, which have been best characterized in a large pedigree called the KE family. The encoded protein is highly conserved in many vertebrates and is expressed in homologous brain regions required for sensorimotor integration and motor-skill learning, in particular cortico-striatal circuits. Independent studies in multiple species suggest that the striatum is a key site of FOXP2 action. Here we used recordings in awake behaving mice to investigate the effects of the KE-family mutation on the function of striatal circuits during motor-skill learning. We uncovered abnormally high ongoing striatal activity in mice carrying an identical mutation to that of the KE-family. Furthermore, there were dramatic alterations in striatal plasticity during the acquisition of a motor-skill, with most neurons in mutants showing negative modulation of firing rate, starkly contrasting with the predominantly positive modulation seen in control animals. We also observed striking changes in the temporal coordination of striatal firing during motor-skill learning in mutants. Our results indicate that FOXP2 is critical for the function of striatal circuits , which are important not only for speech but also for other striatal-dependent skills.
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Dates et versions

hal-00675395 , version 1 (01-03-2012)

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Rui M Costa, Catherine Ann French, Xin Jin, Thomas G Campbell, Elissa Gerfen, et al.. An Aetiological Mutation Causes Aberrant Striatal Activity and Alters Plasticity during Skill Learning. Molecular Psychiatry, 2011, ⟨10.1038/mp.2011.105⟩. ⟨hal-00675395⟩

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