Anthropogenic and natural climate change affect processes in the atmosphere, biosphere, hydrosphere, and pedosphere. The impact of climate on soil evolution has not been well-explored, largely due to slow rates and the complexity of coupled processes that must be observed and simulated. The rates of mineral weathering in loess deposited 23 kyr ago and experienc- ing soil formation for 13 kyr are explored here using the WITCH model for weathering and the GENESIS model for climate simulation. The WITCH model, which uses rigorous kinetic parameters and laws with provision for the effect on rates of devi- ation from equilibrium, can successfully simulate the depletion profiles in the soil for dolomite and albite if soil CO2 is assumed to rise over the last 10 kyr up to about 30-40ﰎ the present atmospheric pressure, and if the solubility product of the Ca-smectite is assumed equal to that of an Fe(III)-rich Ca-montmorillonite. Such simulations document that dissolution behavior for silicates and carbonates are strongly coupled through pH, and for Ca-smectite and feldspars through dissolved silica. Such coupling is not incorporated in simple geometric and analytical models describing mineral dissolution, and there- fore probably contributes to the long-standing observation rates.