The Fraction of a-Linolenic Acid Present in the sn-2 Position of Structured Triacylglycerols Decreases in Lymph Chylomicrons and Plasma Triacylglycerols during the Course of Lipid Absorption in Rats 1-3 - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Nutrition Année : 2012

The Fraction of a-Linolenic Acid Present in the sn-2 Position of Structured Triacylglycerols Decreases in Lymph Chylomicrons and Plasma Triacylglycerols during the Course of Lipid Absorption in Rats 1-3

Résumé

Little is known about the ability of a-linolenic acid (Ln) to remain in the sn-2 position of TG during the absorption process. The goal of this study was to determine the Ln distribution in the lymph (Study 1) and plasma (Study 2) TG of rats fed a single i.g. load of structured TG [300 mg/rat of either oleic acid (O)/Ln/O TG (OLnO) or Ln/O/O TG (LnOO), n = 7 rats]. In an early fraction (3-4 h) of lymph (OLnO group; 100%Ln in the sn-2 position), 46 6 2%Ln was maintained in this position in lymph TG. There was even less (29 6 6%) in the last fraction (7-24 h) (P , 0.05). Ln was also found (9 6 3%) in the sn-2 position of lymph TG in the LnOO group. The Ln content in lymph phospholipids was twice as high in rats when they were fed LnOO (4.2 6 0.1%) than OLnO (2.3 6 0.2%) (P , 0.005). Six hours postprandially (Study 2), 21 6 3% of the Ln incorporated into plasma TG was located in the sn-2 position in the OLnO group compared to 13 6 2%in the LnOO group (P , 0.001). Overall, these results indicate that the amount of Ln that moved fromthe sn-2 position of structured TG to the sn-1(3) position of lymph TG increased during absorption. This may account for a substantial hydrolysis of the 2-monolinolenylglycerols in enterocytes, leading to the intramolecular redistribution of Ln in lymph TG and, consequently, in plasma TG.

Domaines

Chimie organique

Dates et versions

hal-00656066 , version 1 (03-01-2012)

Identifiants

Citer

Leslie Couëdelo, Carole Vaysse, Emilie Vaique, Alexandre Guy, Isabelle Gosse, et al.. The Fraction of a-Linolenic Acid Present in the sn-2 Position of Structured Triacylglycerols Decreases in Lymph Chylomicrons and Plasma Triacylglycerols during the Course of Lipid Absorption in Rats 1-3. Journal of Nutrition, 2012, 142, pp.70-75. ⟨10.3945/jn.111.146290⟩. ⟨hal-00656066⟩
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