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Article Dans Une Revue Science and Technology of Advanced Materials Année : 2011

beta-TCP porous pellets as an orthopaedic drug delivery system: ibuprofen/carrier physicochemical interactions

Hiva Baradari
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Chantal Damia
Eric Champion
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Dominique Chulia
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Marylène Viana
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Résumé

Calcium phosphate bone substitute materials can be loaded with active substances for in situ, targeted drug administration. In this study, porous -TCP pellets were investigated as an anti-inflammatory drug carrier. Porous -TCP pellets were impregnated with an ethanolic solution of ibuprofen. The effects of contact time and concentration of ibuprofen solution on drug adsorption were studied. The ibuprofen adsorption equilibrium time was found to be one hour. The adsorption isotherms fitted to the Freundlich model, suggesting that the interaction between ibuprofen and -TCP is weak. The physicochemical characterizations of loaded pellets confirmed that the reversible physisorption of ibuprofen on -TCP pellets is due to Van der Waals forces, and this property was associated with the 100% ibuprofen release.

Dates et versions

hal-00650032 , version 1 (09-12-2011)

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Citer

Hiva Baradari, Chantal Damia, Maggy Colas, Eric Champion, Dominique Chulia, et al.. beta-TCP porous pellets as an orthopaedic drug delivery system: ibuprofen/carrier physicochemical interactions. Science and Technology of Advanced Materials, 2011, 12, pp.055008-1-055008-10. ⟨10.1088/1468-6996/12/5/055008⟩. ⟨hal-00650032⟩
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