A new mathematical model for optimizing the combination between antiangiogenic and cytotoxic drugs in oncology

We present in this paper a new mathematical model designed to optimize and to rationalize the association between cytotoxic and antiangiogenic drugs in the treatment of a primary tumor. This model takes into account the non-linear interlinkings between both drugs. In particular, this original model integrates the influence of the vasculature state on the delivery of the drugs to the tumor. In the future, this model could be used in clinical oncology to optimize antiangiogenic-based combinational regimen so as to ensure a maximum efficacy.

Mots clés

Cancer modelling therapy modelling

Domaines

Analyse numérique [math.NA]

Fichier principal

cras_2011_newnew_hal.pdf (162.88 Ko)

Origine	Fichiers produits par l'(les) auteur(s)

Florence Hubert : Connectez-vous pour contacter le contributeur

https://hal.science/hal-00641476

Soumis le : mardi 15 novembre 2011-23:05:39

Dernière modification le : mercredi 9 octobre 2024-09:52:02

Archivage à long terme le : vendredi 16 novembre 2012-11:00:47

Dates et versions

hal-00641476 , version 1 (15-11-2011)

hal-00641476 , version 2 (06-02-2012)

Identifiants

HAL Id : hal-00641476 , version 1
DOI : 10.1016/j.crma.2011.11.019

Citer

Sébastien Benzekry, Guillemette Chapuisat, Joseph Ciccolini, Alice Erlinger, Florence Hubert. A new mathematical model for optimizing the combination between antiangiogenic and cytotoxic drugs in oncology. Comptes rendus de l'Académie des sciences. Série I, Mathématique, 2012, 350, pp.23--28. ⟨10.1016/j.crma.2011.11.019⟩. ⟨hal-00641476v1⟩

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