NMDA-dependent metaplasticity at hippocampal mossy fiber synapses - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nature Neuroscience Année : 2011

NMDA-dependent metaplasticity at hippocampal mossy fiber synapses

Résumé

Hippocampal mossy fiber synapses (Mf-synapses) have been reported to lack NMDA receptor-dependent LTP of AMPA-EPSCs, unlike conventional glutamatergic synapses. An explanation for this difference may reside in the relatively low amount of NMDA receptors at these synapses. Because Mf-synapses display LTP selective for NMDA receptors, we examined whether this would impact on the plasticity rules at Mf-CA3 synapses in mouse hippocampal slices. Here we show that LTP of NMDA receptors serves as a metaplastic switch making Mf- synapses competent for generating NMDA receptor-dependent LTP of AMPA-EPSCs.
Fichier principal
Vignette du fichier
PEER_stage2_10.1038%2Fnn.2809.pdf (25.2 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-00637331 , version 1 (01-11-2011)

Identifiants

Citer

Nelson Rebola, Fréderic Lanore, Christophe Blanchet, Mario Carta, Christophe Mulle. NMDA-dependent metaplasticity at hippocampal mossy fiber synapses. Nature Neuroscience, 2011, ⟨10.1038/nn.2809⟩. ⟨hal-00637331⟩

Collections

CNRS PEER
45 Consultations
64 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More