NMDA-dependent metaplasticity at hippocampal mossy fiber synapses
Résumé
Hippocampal mossy fiber synapses (Mf-synapses) have been reported to lack NMDA receptor-dependent LTP of AMPA-EPSCs, unlike conventional glutamatergic synapses. An explanation for this difference may reside in the relatively low amount of NMDA receptors at these synapses. Because Mf-synapses display LTP selective for NMDA receptors, we examined whether this would impact on the plasticity rules at Mf-CA3 synapses in mouse hippocampal slices. Here we show that LTP of NMDA receptors serves as a metaplastic switch making Mf- synapses competent for generating NMDA receptor-dependent LTP of AMPA-EPSCs.
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