Article Dans Une Revue Convergence Année : 2011

Combined measurement of PEDF, haptoglobin and tau in cerebrospinal fluid improves the diagnostic discrimination between alzheimer's disease and other dementias.

Jean-Daniel Abraham
  • Fonction : Auteur
Sophie Calvayrac-Pawlowski
  • Fonction : Auteur
Sandra Cobo
  • Fonction : Auteur
Nicolas Salvetat
  • Fonction : Auteur
Guillaume Vicat
  • Fonction : Auteur
Laurence Molina
Jacques Touchon
  • Fonction : Auteur
Bernard-François Michel
  • Fonction : Auteur
Franck Molina
Jeannette Fareh
  • Fonction : Auteur
Chantal Mourton-Gilles
  • Fonction : Auteur

Résumé

Using proteomic approach in cerebrospinal fluid (CSF) we identified pigment epithelium-derived factor (PEDF) and Haptoglobin (Hp) as putative markers that could discriminate between AD and other dementias. ELISA assays were developed to measure the levels of PEDF and Hp in CSF from patients with AD (AD, n=27), non-AD (NAD, n=30) and in non-demented patients (ND, n=27). The combined assessment of PEDF, Hp and Tau levels, using Iterative Marginal Optimization, improved the differential diagnosis of AD, especially in patients with moderate to severe dementia (p<0.002). This pilot study highlights the probable different contribution of oxidative mechanisms in dementia.

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Dates et versions

hal-00636453 , version 1 (27-10-2011)

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Citer

Jean-Daniel Abraham, Sophie Calvayrac-Pawlowski, Sandra Cobo, Nicolas Salvetat, Guillaume Vicat, et al.. Combined measurement of PEDF, haptoglobin and tau in cerebrospinal fluid improves the diagnostic discrimination between alzheimer's disease and other dementias.. Convergence, 2011, 16 (2), pp.161-71. ⟨10.3109/1354750X.2010.536995⟩. ⟨hal-00636453⟩
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