Article Dans Une Revue New Journal of Chemistry Année : 2011

Encapsulation and controlled release of L-leuprolide from poly(β-hydroxyalkanoate)s: impact of microstructure and chemical functionalities

Résumé

A systematic study on the encapsulation and drug release efficiency of L-leuprolide acetate (LeA) with a series of different functionalized poly(β-hydroxyalkanoate)s (PHAs) is reported. Significant differences on the in vitro release kinetics of LeA, depending essentially on the microstructure, chemical functionality, and molecular weights of polymers, have been evidenced. Better controlled released kinetics were observed with highly isotactic poly(β-hydroxybutyrate) (i-PHB) and syndiotactic dihydroxylated-PHA.

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Dates et versions

hal-00632159 , version 1 (13-10-2011)

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Noureddine Ajellal, Christophe M. Thomas, Thierry Aubry, Yves Grohens, Jean-François Carpentier. Encapsulation and controlled release of L-leuprolide from poly(β-hydroxyalkanoate)s: impact of microstructure and chemical functionalities. New Journal of Chemistry, 2011, 35 (4), pp.876-880. ⟨10.1039/C0NJ00998A⟩. ⟨hal-00632159⟩
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