Encapsulation and controlled release of L-leuprolide from poly(β-hydroxyalkanoate)s: impact of microstructure and chemical functionalities
Résumé
A systematic study on the encapsulation and drug release efficiency of L-leuprolide acetate (LeA) with a series of different functionalized poly(β-hydroxyalkanoate)s (PHAs) is reported. Significant differences on the in vitro release kinetics of LeA, depending essentially on the microstructure, chemical functionality, and molecular weights of polymers, have been evidenced. Better controlled released kinetics were observed with highly isotactic poly(β-hydroxybutyrate) (i-PHB) and syndiotactic dihydroxylated-PHA.