The use of robust and accurate Eulerian/Eulerian formulations in the modeling of reactive two-phase flow would be a major step forward in the framework of turbulent combustion modeling with massively parallel supercomputers. Therefore, the ability of the Eulerian multi-fluid model to capture all stages of turbulent spray combustion has been tested and compared with a usual Lagrangian formulation. The multi-fluid model and related dedicated schemes and algorithms are able to characterize properly the spray dispersion and segregation as well as the vaporization dynamics leading to the fuel mass fraction topology. Eventually, flame propagation and structure in 2D and 3D forced isotropic homogeneous turbulence have been characterized showing the capacity of the multi-fluid model to simulate such reactive flows with results with the same level of accuracy as a baseline solution obtained with Lagrangian droplet tracking.