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Article Dans Une Revue Polymer international Année : 2011

New amoxicillin-poly(lactic acid)-based conjugates: synthesis and in vitro release of amoxicillin

Résumé

Long-term antibiotic treatments are required to cure many diseases. Coupling a bioactive compound to a biocompatible polymer offers, in general, many advantages such as better stabilization of drug and controlled release. The work reported deals with the synthesis of newconjugates based on amoxicillin and oligomers of biocompatible and biodegradable poly(lactic acid), as well as release studies of amoxicillin. These new conjugates were obtained via a Curtius rearrangement or acyl chloride activation, leading to substituted urea or amide bonds between amoxicillin and polymer, respectively. Structures of the conjugates were assessed using Fourier transform infrared and 1H NMR spectroscopy, double-detection size exclusion chromatography and electrospray ionization mass spectrometry. In vitro release profiles of amoxicillin in phosphate buffered saline were determined using high-performance liquid chromatography, and the release rates of amoxicillin from the two conjugates were compared.

Dates et versions

hal-00625975 , version 1 (23-09-2011)

Identifiants

Citer

Hélène van den Berghe, Xavier Garric, Michel Vert, Jean Coudane. New amoxicillin-poly(lactic acid)-based conjugates: synthesis and in vitro release of amoxicillin. Polymer international, 2011, 60, pp.398-404. ⟨10.1002/pi.2960⟩. ⟨hal-00625975⟩
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