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Journal Articles Journal of Theoretical Biology Year : 2010

On the proportion of cancer stem cells in a tumour

Abstract

It is now generally accepted that cancers contain a sub-population, the cancer stem cells (CSCs), that initiate and drive a tumour's growth. At least until recently it has been widely assumed that only a small proportion of the cells in a tumour are CSCs. Here we use a mathematical model, supported by experimental evidence, to show that such an assumption is unwarranted. We show that CSCs may comprise any possible proportion of the tumour, and that the higher the proportion the more aggressive the tumour is likely to be.
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Dates and versions

hal-00620585 , version 1 (08-09-2011)

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Matthew D. Johnston, Philip K. Maini, S. Jonathan Chapman, Carina M. Edwards, Walter F. Bodmer. On the proportion of cancer stem cells in a tumour. Journal of Theoretical Biology, 2010, 266 (4), pp.708. ⟨10.1016/j.jtbi.2010.07.031⟩. ⟨hal-00620585⟩

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