New Lipo-Phosphoramidates for Gene Delivery
Résumé
Lipo-phosphoramidates constitute an interesting class of synthetic vectors for gene delivery. A structure-activity relationship study points out that the incorporation of the linoleyl polyunsaturated lipid chains produces efficient vectors for gene delivery in the lung. In addition, neutral lipo-phosphoramidates possessing an imidazole motif in the polar head region have been successfully employed in association with a cationic lipophosphoramide to improve in vitro transfection efficiencies. Our recent achievements on this topic are briefly summarized here.