Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cell Host and Microbe Année : 2011

Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity.

Résumé

The cuticle and epidermis of Caenorhabditis elegans provide the first line of defense against invading pathogens. Upon invasion by the fungal pathogen Drechmeria coniospora, C. elegans responds by upregulating the expression of antimicrobial peptides (AMPs) in the epidermis via activation of at least two pathways, a neuroendocrine TGF-β pathway and a p38 MAPK pathway. Here, we identify the sodium-neurotransmitter symporter SNF-12, a member of the solute carrier family (SLC6), as being essential for both these immune signaling pathways. We also identify the STAT transcription factor-like protein STA-2 as a direct physical interactor of SNF-12 and show that the two proteins function together to regulate AMP gene expression in the epidermis. Both SNF-12 and STA-2 act cell autonomously and specifically in the epidermis to govern the transcriptional response to fungal infection. These findings reveal an unorthodox mode of regulation for a STAT factor and highlight the molecular plasticity of innate immune signaling.

Domaines

Immunologie

Dates et versions

hal-00611411 , version 1 (26-07-2011)

Identifiants

Citer

Katja Dierking, Jolanta Polanowska, Shizue Omi, Ilka Engelmann, Marta Gut, et al.. Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity.. Cell Host and Microbe, 2011, 9 (5), pp.425-35. ⟨10.1016/j.chom.2011.04.011⟩. ⟨hal-00611411⟩
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