A platinum Chugaev carbene complex as a potent anticancer agent - Archive ouverte HAL
Article Dans Une Revue Chemical Communications Année : 2011

A platinum Chugaev carbene complex as a potent anticancer agent

Résumé

A platinum Chugaev complex was synthesised and fully characterized by multinuclear NMR spectroscopy and X-ray crystallography. This cis bis acyclic diamino carbene complex acts as a cytotoxic compound and behaves as a cisplatin equivalent by interacting with supercoiled DNA and thiols. Stability of the ligand is also discussed.

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https://hal.science/hal-00609652

Soumis le : mardi 19 juillet 2011-16:16:54

Dernière modification le : mardi 19 novembre 2024-03:27:54

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hal-00609652 , version 1 (19-07-2011)

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  • HAL Id : hal-00609652 , version 1

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Georges Alves, Laurent Morel, Malika El-Ghozzi, Daniel Avignant, Bertrand Legeret, et al.. A platinum Chugaev carbene complex as a potent anticancer agent. Chemical Communications, 2011, 47, pp.7830-7832. ⟨hal-00609652⟩

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