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Article Dans Une Revue Organic Letters Année : 2011

A Simple Copper-Catalyzed Synthesis of Tertiary Acyclic Amides

Résumé

The N-arylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper catalytic system. The corresponding tertiary acyclic amides, which can be found in numerous biologically active compounds, have been obtained in good to excellent yields.

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Chimie organique
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Dates et versions

hal-00604512 , version 1 (29-06-2011)

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Emilie Racine, Florian Monnier, Jean-Pierre Vors, Marc Taillefer. A Simple Copper-Catalyzed Synthesis of Tertiary Acyclic Amides. Organic Letters, 2011, 13 (11), pp.2818-2821. ⟨10.1021/ol200750p⟩. ⟨hal-00604512⟩
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