The use of statins potentiates the insulin sensitizing effect of exercise training in obese males with and without type 2 diabetes.
Résumé
Abstract Exercise-training is advocated in insulin resistance and statins are used to treat hyperlipidemia, two cardiometabolic risk-factors often presenting concurrently. Statin intake may blunt mitochondrial function and the adaptive response to exercise training. Thus, combining exercise training with statins administration may have adverse effects. We examined if improvements in cardiometabolic risk-factors, insulin sensitivity and mitochondrial function mediated by progressive exercise training are affected by statin use. Methods Fourteen obese elderly males on statins (ST) and 22 matched control subjects (C) were examined. Results on in vivo mitochondrial function (MRS), mitochondrial density (western blot), insulin sensitivity (clamp) and metabolic flexibility (indirect calorimetry) were compared before and after the 12 week combined progressive training program (3x/week, 45 minutes/session). Results Except for LDL cholesterol, all pre-training values were comparable between statin users and control subjects. In vivo mitochondrial function (MRS) and mitochondrial density (western blot) improved by training in both groups. Interestingly, blood-lipid profile, insulin sensitivity (+72%) (clamp), non-oxidative and oxidative glucose disposal (+38% and +112%) and insulin-mediated suppression of fat oxidation (-62%) (indirect calorimetry) improved only in ST. Conclusion Statin treatment did not impede exercise performance or tolerance, mitochondrial function or mass. In addition, training-induced improvements in glucose homeostasis were preserved in ST. Strikingly, the insulin sensitizing effect of training was more prominent in ST than in C. The combined prescription of statins along with exercise training is safe and should be considered for subjects prone to develop insulin resistance.
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