The use of statins potentiates the insulin sensitizing effect of exercise training in obese males with and without type 2 diabetes. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Clinical Science Année : 2010

The use of statins potentiates the insulin sensitizing effect of exercise training in obese males with and without type 2 diabetes.

Ruth Cr Meex
  • Fonction : Auteur
Esther Phielix
  • Fonction : Auteur
Vera B Schrauwen-Hinderling
  • Fonction : Auteur
Esther Moonen-Kornips
  • Fonction : Auteur
Gert Schaart
  • Fonction : Auteur
Patrick Schrauwen
  • Fonction : Auteur

Résumé

Abstract Exercise-training is advocated in insulin resistance and statins are used to treat hyperlipidemia, two cardiometabolic risk-factors often presenting concurrently. Statin intake may blunt mitochondrial function and the adaptive response to exercise training. Thus, combining exercise training with statins administration may have adverse effects. We examined if improvements in cardiometabolic risk-factors, insulin sensitivity and mitochondrial function mediated by progressive exercise training are affected by statin use. Methods Fourteen obese elderly males on statins (ST) and 22 matched control subjects (C) were examined. Results on in vivo mitochondrial function (MRS), mitochondrial density (western blot), insulin sensitivity (clamp) and metabolic flexibility (indirect calorimetry) were compared before and after the 12 week combined progressive training program (3x/week, 45 minutes/session). Results Except for LDL cholesterol, all pre-training values were comparable between statin users and control subjects. In vivo mitochondrial function (MRS) and mitochondrial density (western blot) improved by training in both groups. Interestingly, blood-lipid profile, insulin sensitivity (+72%) (clamp), non-oxidative and oxidative glucose disposal (+38% and +112%) and insulin-mediated suppression of fat oxidation (-62%) (indirect calorimetry) improved only in ST. Conclusion Statin treatment did not impede exercise performance or tolerance, mitochondrial function or mass. In addition, training-induced improvements in glucose homeostasis were preserved in ST. Strikingly, the insulin sensitizing effect of training was more prominent in ST than in C. The combined prescription of statins along with exercise training is safe and should be considered for subjects prone to develop insulin resistance.

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Dates et versions

hal-00603436 , version 1 (25-06-2011)

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Ruth Cr Meex, Esther Phielix, Vera B Schrauwen-Hinderling, Esther Moonen-Kornips, Gert Schaart, et al.. The use of statins potentiates the insulin sensitizing effect of exercise training in obese males with and without type 2 diabetes.. Clinical Science, 2010, 119 (7), pp.293-301. ⟨10.1042/CS20100153⟩. ⟨hal-00603436⟩

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