Epigenetic regulation of antigen receptor gene rearrangement. - Archive ouverte HAL Access content directly
Journal Articles F1000 Biol Rep Year : 2010

Epigenetic regulation of antigen receptor gene rearrangement.

Abstract

V(D)J recombination assembles antigen-specific immunoglobulin and T-cell receptor variable region genes from germline V, D, and J segments during lymphocyte development. Regulation of this site-specific DNA rearrangement process occurs with respect to the cell type and stage of differentiation, order of locus recombination, and allele usage. Many of these controls are mediated via the modulation of gene accessibility to the V(D)J recombinase. Here, we summarise recent advances regarding the impact of nuclear organisation and epigenetic-based mechanisms on the regulation of V(D)J recombination.

Dates and versions

hal-00601949 , version 1 (21-06-2011)

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Salvatore Spicuglia, Joaquin Zacarias-Cabeza, Aleksandra Pekowska, Pierre Ferrier. Epigenetic regulation of antigen receptor gene rearrangement.. F1000 Biol Rep, 2010, 2, 2:pii 23. ⟨10.3410/B2-23⟩. ⟨hal-00601949⟩

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CNRS UNIV-AMU
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