Tyrosine phosphatase inhibition triggers sustained canonical Serine-dependent NFκB activation via Src-dependent blockade of PP2A
Résumé
Activation status of Tyr-kinase Src as well as of the transcription factor NFκB is a decisive criterion for the onset of cancer and in conveying radio-resistance. While the activation status of Src is Tyr-phosphorylation dependent, NFκB activation requires Ser phosphorylation of its cytosolic inhibitor, IκBα⋅ Since constitutive NFκB activation was linked to tumor maintenance, its tight regulation is mandatory.
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